Mouse IG Reference Sets Updated

Fixes have been made to two mouse reference sets. In C57BL/6 IGH, a stray character in the coding sequence for IGHV-KAOG has been removed. There are no other changes to this set. In PWD/PhJ IGH, the delineation j_cdr3_end has been corrected. There are no other changes in this set, and coding sequences are unchanged.

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Human IG Reference Sets Updated

The human IG reference sets on OGRDB have been updated and carry new versions, but no coding sequences are affected. The updates add longer gene sequences for many light-chain alleles, allowing better characterisation of leader and RSS. Delineations of CDRs and other features have been reviewed and fixed in some cases. The changes made are… Continue reading Human IG Reference Sets Updated

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Genomic data extended

Genomic data has been extended to include 36 human IGK samples from Engelbrecht, Rodriguez, Shields et al., 2024. We have replaced the 22 human IGL samples published in Gibson, Rodriguez, Shields et al., 2022 with 200 that have been processed with more accurate sequencing and pipelines than were available for that study. The IGL and… Continue reading Genomic data extended

OGRDB Updated

OGRDB has been updated to use binomial (latin) species names instead of colloquial names. The former names can still be used in calls to fetch germline sets, which I hope will prevent automated scripts from breaking, but if you do have problems please try substituting, for example, “Homo sapiens” for “Human”. This turned out to… Continue reading OGRDB Updated

Collaboration Opportunities

OGRDB and VDJbase are part of the AIRR Knowledge Commons project – bringing together immune repertoires from the AIRR Data Commons, epitopes from IEDB, receptor germline analysis from OGRDB and VDJbase with other emerging datasets. We are actively seeking collaborators whose projects will drive use cases and demonstrate the utility of bringing these various sources… Continue reading Collaboration Opportunities

Novel Allele Submission Process Simplified

Following an IARC decision in December 2023, the submission process for inferred novel alleles has been simplified. Previously, it was necessary to deposit the sequence of each inferred allele in GenBank or ENA, and it was usually necessary to accompany this with an extracted set of reads from the repertoire that provided explicit support for… Continue reading Novel Allele Submission Process Simplified

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Germline Databases, or adventures into the allelic underworld

If you are interested in receptor germlines, you might enjoy this On-AIRR podcast with Corey Watson and William Lees, hosted by Ulrik Stervbo and Zhaoqing Ding. “In this episode we talk about the recent work by the Germline Database Working Group of the AIRR-Community. The accuracy of V and J gene segment assignment improves with… Continue reading Germline Databases, or adventures into the allelic underworld

Genomic databases updated

We have updated the genomic databases to follow the same project/individual/sample structure that is used for AIRR-seq databases – previously we only structured genomic databases into project/individual. This change makes it easier to handle datasets that have more than one analysis of the same individual – as can be seen, for example, in the human… Continue reading Genomic databases updated

Human IG germline sets now available

Germline sets for human IGH, IGK and IGL are now available for download. They are described in a forthcoming publication, “AIRR-C Human IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genes”, currently available from Biorxiv as a preprint. Our aim with these sets is to provide high-quality, evidenced collections that are… Continue reading Human IG germline sets now available

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